bioRxiv2025
DISCO-seq: 3D single-cell transcriptomics of intact biological systems
Harsharan S. Bhatia et al.
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Cell · 2022
DISCO-MS
Spatial proteomics inside cleared organs
DISCO-MS pipeline on 5xFAD brain
Step-by-step DISCO-MS pipeline illustrated on a 5xFAD mouse brain (6 weeks old). LCM extracted ROIs around the single plaques subjected to ultra-high sensitive mass spectrometry based proteome analyses.
Combines 3D imaging with AI-guided robotic extraction and mass spectrometry — spatial proteomics directly in optically cleared pre-clinical and clinical specimens.
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