Cell · 2019

DeepMACT

AI-detected cancer metastasis across the whole body

Torso metastasis mapping

3D reconstruction of a mouse torso scanned by light-sheet microscopy. The left side shows the segmented view, in which the torso is represented in gray, the lungs in yellow and the heart in green. The right side shows the original 2D data from the light-sheet microscopy. Various macro- and micro-metastases (magenta) are visualized in high contrast over the background.

Integrates vDISCO tissue clearing, light-sheet microscopy, and deep learning to find micrometastases and quantify therapeutic antibody targeting at single-cell level — 300× faster than manual annotation.

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