Nature Biotechnology2023
Whole-body cellular mapping in mouse using standard IgG antibodies
Hongcheng Mai et al.
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Nature Biotechnology · 2023
wildDISCO
Whole-body cellular maps with standard antibodies
PGP 9.5 peripheral nerve map
3D reconstruction of a mouse labeled with PGP 9.5 and imaged with light-sheet microscopy. Different PGP 9.5 innervation regions (green) are visualized with high contrast over background (gray).
Whole-body immunolabeling with standard IgG antibodies and DISCO clearing. Maps nervous, lymphatic, and vascular systems at cellular resolution — no transgenic mice required.
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